In 2010, 43 percent of deaths in the world occurred at age 70 and older, compared with 33 percent of deaths in 1990, the report said. And fewer child deaths have brought up the mean age of death, which in Brazil and Paraguay jumped to 63 in 2010, up from 30 in 1970, the report said. The measure, an average of all deaths in a given year, is different from life expectancy, and is lower when large... numbers of children die. But while developing countries made big strides the United States stagnated. American women registered the smallest gains in life expectancy of all high-income countries’ female populations between 1990 and 2010. American women gained just under two years of life, compared with women in Cyprus, who lived 2.3 years longer and Canadian women who gained 2.4 years. The slow increase caused American women to fall to 36th place in the report’s global ranking of life expectancy, down from 22nd in 1990. Life expectancy for American women was 80.5 in 2010, up from 78.6 in 1990.
Common cancer is an age-related disease. Slow aging is associated with reduced and delayed carcinogenesis. Calorie restriction (CR), the most studied anti-aging intervention, prevents cancer by slowing down the aging process. Evidence is emerging that CR decelerates aging by deactivating MTOR (Target of Rapamycin). Rapamycin and other rapalogs suppress cellular senescence, slow down aging and... postpone age-related diseases including cancer. At the same time, rapalogs are approved for certain cancer treatments. Can cancer prevention be explained by direct targeting of cancer cells? Or does rapamycin prevent cancer indirectly through slowing down the aging process? Increasing evidence points to the latter scenario.
Should we blame all the higher costs of clinical trials on the regulatory bodies, like FDA? No, suggests a new study from Tuft's Center for the Study of Drug Discovery. The study claims that one 1 in 5 procedures performed in late stage drug development is done to pursue "supplementary secondary, tertiary, and exploratory endpoints." This adds on average $1.1 M per trial. Across the industry that accounts for $4B to $6B per year for non-core endpoints -- enough to fund 2 x 2 Presidential campaigns
After a chilly start to 2012, average temperatures from January to October were 0.45 degrees Celsius, or 0.81 degrees Fahrenheit, above the average from 1961 to 1990, according to the World Meteorological Organization’s findings. A rise of only one degree Celsius was sufficient to increase the frequency of extreme weather events, Mr. Jarraud said.
Julie Brigham Grette, a professor at the University of Massachusetts Amherst, believes the recent Hurricane Sandy demonstrates just how important a solid understanding of the rising sea-level is. “People don’t understand why we’re talking about a few millimeters,” she said. “A half-foot of rise on the Eastern Seaboard makes it easier for a storm coming up the East Coast to cause flooding.”
Inner work life influences people’s performance on four dimensions: creativity, productivity, work commitment, and collegiality. We call this the inner work life effect
Founders, iconoclasts, and visionaries, their inspiration could be hard-core technology, e-commerce, hamburgers, rental cars, biotech, or a new take on social networking—it doesn’t matter. These people are consumed by a deep passion and driving hunger to translate their purpose into reality.
Fibroproliferative disorders such as idiopathic pulmonary fibrosis and systemic sclerosis have no effective therapies and result in significant morbidity and mortality due to progressive organ fibrosis. We examined the effect of peptides derived from endostatin on existing fibrosis and fibrosis triggered by two potent mediators, transforming growth... factor–β (TGF-β) and bleomycin, in human and mouse tissues in vitro, ex vivo, and in vivo. We identified one peptide, E4, with potent antifibrotic activity. E4 prevented TGF-β–induced dermal fibrosis in vivo in a mouse model, ex vivo in human skin, and in bleomycin-induced dermal and pulmonary fibrosis in vivo, demonstrating that E4 exerts potent antifibrotic effects. In addition, E4 significantly reduced existing fibrosis in these preclinical models. E4 amelioration of fibrosis was accompanied by reduced cell apoptosis and lower levels of lysyl oxidase, an enzyme that cross-links collagen, and Egr-1 (early growth response gene–1), a transcription factor that mediates the effects of several fibrotic triggers. Our findings identify E4 as a peptide with potent antifibrotic activity and a possible therapeutic agent for organ fibrosis.
The kind of trust that is necessary to build a great team is what I call vulnerability-based trust. This is what happens when members get to a point where they are completely comfortable being transparent, honest, and naked with one another, where they say and genuinely mean things like “I screwed up,” “I need help,” “Your idea is better than mine,” “I wish I could learn to do that as well as you do,” and even, “I’m sorry.
Swiss scientists have demonstrated how a partially paralyzed person can control a robot by thought alone, a step they hope will one day allow immobile people to interact with their surroundings through so-called avatars.
remember that you can measure almost anything—and what you measure will almost certainly “improve.” And as the Crosby Quality Institute reminds us: You will get what you inspect, not what you
In this case, the researchers studied a tumor suppressor commonly lost in human cancers. Mice with an extra copy of the gene known as Pten didnt get cancer, but thats not the half of it. Those mice were also leaner, even as they ate more than controls, Serrano said. That suggested that the animals were experiencing some sort of metabolic imbalance -- and a beneficial one at that. Cancer... protection aside, the animals lived longer than usual. They were also less prone to insulin resistance and had less fat in their livers. Those benefits seem to trace back to the fact that those Pten mice were burning more calories thanks to overactive brown fat. Studies in isolated brown fat cells confirmed that a boost in Pten increases the activity of those cells. Pten also made it easier for brown fat to form.
Hospital costs were a huge political issue throughout the 1970s. Jimmy Carter unsuccessfully tried to pass price controls, but ultimately, the government settled on a system that paid a fixed reimbursement for a given class of problem, rather than just paying the hospital for however long they'd care to keep patient. (A system known as Diagnostic Related Groups, or DRGs). The length of hospital visits dropped like a stone--from an average of 7.5 days in 1980 to 4.8 today. Most of that change was accomplished by 1995.
The more negative the bosses' management style, the less happy the workers -- not a surprising finding. When bosses were controlling rather than encouraging, employee well-being was low. On the other hand, when employees felt that their autonomy was encouraged (for example, when bosses gave a "meaningful rationale for doing the tasks" and made employees feel they were being asked to contribute rather than commanded to do something), they also had better overall well-being.
Six Sigma seeks at best a refinement of existing processes and products. The method may buttress existing processes that are actually barriers to innovation, rather than seek to significantly change or replace those processes. Further magnifying the problem, Six Sigma was initially introduced by third-party consultants, but over time many organizations have developed deep internal capabilities to... deploy Six Sigma tools and techniques. Many of these internal Six Sigma experts, often called “green belts” or “black belts” based on their training and experience, become defenders of the very processes they are meant to
AT THE HEART OF EVERY HYBRID automobile lies a regenerative brake. Traditional brakes dissipate the energy produced by a vehicle’s motion, generating friction and useless heat. Regenerative brakes, by contrast, capture the energy and put it back to work. An electrical generator built into the brake recharges the hybrid’s massive batteries as the car
Of the 36 million Americans 65 and older, at least 20 percent take at least one anticholinergic medication. A study by Dr. Boustani of nearly 4,000 older adults in Indianapolis found that those who had been using three or more possibly anticholinergic drugs consistently for 90 days or longer were nearly three times as likely to receive a diagnosis of mild cognitive impairment as those who had not taken anticholinergics.